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Article

Ion Torrent next-generation sequencing for routine identification of clinically relevant mutations in colorectal cancer patients.

Journal of clinical pathology - 1 Jan 2015

Malapelle Umberto, Vigliar Elena, Sgariglia Roberta, Bellevicine Claudio, Colarossi Lorenzo, Vitale Domenico, Pallante Pierlorenzo, Troncone Giancarlo

Abstract excerpt

AIMS: To evaluate the accuracy, consumable cost and time around testing (TAT) of a next-generation sequencing (NGS) assay, the Ion Torrent AmpliSeq Colon and Lung Cancer Panel, as an alternative to Sanger sequencing to genotype KRAS, NRAS and BRAF in colorectal cancer patients. METHODS: The Ion Torrent panel was first verified on cell lines and on control samples and then prospectively applied to routine...

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Source

Identifiers

PMID: 25378536
DOI: 10.1136/jclinpath-2014-202691

Genes

BRAF
KRAS
NRAS
TAT
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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