Article
Detection of therapeutically relevant and concomitant rare somatic variants in colorectal cancer.
Neoplasma - 1 Nov 2021
Mikolajcik Peter, Lasabova Zora, Loderer Dusan, Grendar Marian, Kalman Michal, Kasubova Ivana, Lucansky Vincent, Wiederhold Alexander Johannes, Marcinek Juraj, Burjanivova Tatiana, Kudelova Eva, Vojtko Martin, Svec Adam, Plank Lukas, Janik Jan, Laca Ludovit
Abstract excerpt
In colorectal cancer (CRC), clinically relevant biomarkers are known for genome-guided therapy that can be detected by both first and next generation methods. The aim of our work was to introduce a robust NGS assay that will be able to detect, in addition to standard predictive single nucleotide-based biomarkers, even rare and concomitant clinically relevant variants. Another aim was to identify truncating...
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