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FOXO1 regulates RUNX2 ubiquitination through SMURF2 in calcific aortic valve disease

27 May 2024

Abstract excerpt

The prevalence of calcific aortic valve disease (CAVD) remains substantial while there is currently no medical therapy available. Forkhead box O1 (FOXO1) is known to be involved in the pathogenesis of cardiovascular diseases, including vascular calcification and atherosclerosis; however, its specific role in calcific aortic valve disease remains to be elucidated. In this study, we identified FOXO1 significantly...

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PMID: 38810422
DOI: 10.1016/j.redox.2024.103215

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