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Article

PINK1 as a molecular checkpoint in the maintenance of mitochondrial function and integrity.

Molecules and cells - 1 Jul 2012

Koh Hyongjong, Chung Jongkyeong

Abstract excerpt

Parkinson's disease (PD), the most prevalent neurodegenerative movement disorder, is characterized by an age-dependent selective loss of dopaminergic (DA) neurons. Although most PD cases are sporadic, more than 20 responsible genes in familial cases were identified recently. Genetic studies using Drosophila models demonstrate that PINK1, a mitochondrial kinase encoded by a PD-linked gene PINK1, is critical for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22610403
DOI: 10.1007/s10059-012-0100-8
PMCID: PMC3887784

Genes

PINK1
TRAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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