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Article

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease.

Cell stem cell - 1 Dec 2016

Hsieh Chung-Han, Shaltouki Atossa, Gonzalez Ashley E, Bettencourt da Cruz Alexandre, Burbulla Lena F, St Lawrence Erica, Schüle Birgitt, Krainc Dimitri, Palmer Theo D, Wang Xinnan

Abstract excerpt

Mitochondrial movements are tightly controlled to maintain energy homeostasis and prevent oxidative stress. Miro is an outer mitochondrial membrane protein that anchors mitochondria to microtubule motors and is removed to stop mitochondrial motility as an early step in the clearance of dysfunctional mitochondria. Here, using human induced pluripotent stem cell (iPSC)-derived neurons and other complementary...

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Source

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Identifiers

PMID: 27618216
DOI: 10.1016/j.stem.2016.08.002
PMCID: PMC5135570

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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