Article
Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility.
Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2016
Shlevkov Evgeny, Kramer Tal, Schapansky Jason, LaVoie Matthew J, Schwarz Thomas L
Abstract excerpt
The PTEN-induced putative kinase 1 (PINK1)/Parkin pathway can tag damaged mitochondria and trigger their degradation by mitophagy. Before the onset of mitophagy, the pathway blocks mitochondrial motility by causing Miro degradation. PINK1 activates Parkin by phosphorylating both Parkin and ubiquitin. PINK1, however, has other mitochondrial substrates, including Miro (also called RhoT1 and -2), although the...
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