Stability depends on positive autoregulation in Boolean gene regulatory networks.

Abstract excerpt

Network motifs have been identified as building blocks of regulatory networks, including gene regulatory networks (GRNs). The most basic motif, autoregulation, has been associated with bistability (when positive) and with homeostasis and robustness to noise (when negative), but its general importance in network behavior is poorly understood. Moreover, how specific autoregulatory motifs are selected during...

Topics

• Animals
• Computational Biology
• Diptera
• Gene Regulatory Networks
• Homeostasis
• Mammals
• Models, Biological
• Phenotype
• Yeasts