Bistability in feedback circuits as a byproduct of evolution of evolvability.

doi:10.1038/msb.2011.98

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Article

Bistability in feedback circuits as a byproduct of evolution of evolvability.

Molecular systems biology - 17 Jan 2012

Kuwahara Hiroyuki, Soyer Orkun S

Abstract excerpt

Noisy bistable dynamics in gene regulation can underlie stochastic switching and is demonstrated to be beneficial under fluctuating environments. It is not known, however, if fluctuating selection alone can result in bistable dynamics. Using a stochastic model of simple feedback networks, we apply fluctuating selection on gene expression and run in silico evolutionary simulations. We find that independent of the...

Topics

Adaptation, Biological
Animals
Biological Evolution
Computer Simulation
Environment
Evolution, Molecular
Feedback, Physiological
Gene Regulatory Networks
Gene-Environment Interaction
Genomic Instability
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Models, Biological

Models, Theoretical

Mutation

Phenotype

Selection, Genetic

Stochastic Processes

Source

Open in PubMed Open full text

Identifiers

PMID: 22252387
DOI: 10.1038/msb.2011.98
PMCID: PMC3296359

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