Emergence of cooperative bistability and robustness of gene regulatory networks.

Abstract excerpt

Gene regulatory networks (GRNs) are complex systems in which many genes regulate mutually to adapt the cell state to environmental conditions. In addition to function, the GRNs possess several kinds of robustness. This robustness means that systems do not lose their functionality when exposed to disturbances such as mutations or noise, and is widely observed at many levels in living systems. Both function and...

Topics

• Evolution, Molecular
• Gene Regulatory Networks
• Models, Genetic
• Monte Carlo Method
• Mutation