Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of scale-free topology on the robustness and evolvability of genetic regulatory networks.

Journal of theoretical biology - 7 Nov 2010

Greenbury Sam F, Johnston Iain G, Smith Matthew A, Doye Jonathan P K, Louis Ard A

Abstract excerpt

We investigate how scale-free (SF) and Erdos-Rényi (ER) topologies affect the interplay between evolvability and robustness of model gene regulatory networks with Boolean threshold dynamics. In agreement with Oikonomou and Cluzel (2006) we find that networks with SF(in) topologies, that is SF topology for incoming nodes and ER topology for outgoing nodes, are significantly more evolvable towards specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Clocks
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Regulatory Networks

Share to Models, Genetic

Share to Mutation

Share to Phenotype

Source

Identifiers

PMID: 20696172
DOI: 10.1016/j.jtbi.2010.08.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of scale-free topology on the robustness and evolvability of genetic regulatory networks.PMID 20696172Read ↗

Robustness versus evolvability analysis for regulatory feed-forward loops.Semantic proximity Read ↗

Nonlinear Dynamics in Gene Regulation Promote Robustness and Evolvability of Gene Expression Levels.Semantic proximity Read ↗

Robustness and evolvability in genetic regulatory networks.Semantic proximity Read ↗

Stability depends on positive autoregulation in Boolean gene regulatory networks.Semantic proximity Read ↗

Network topology and the evolution of dynamics in an artificial genetic regulatory network model created by whole genome duplication and divergence.Semantic proximity Read ↗

The influence of assortativity on the robustness of signal-integration logic in gene regulatory networks.Semantic proximity Read ↗

Robustness, evolvability, and the logic of genetic regulation.Semantic proximity Read ↗

Innovation and robustness in complex regulatory gene networks.Semantic proximity Read ↗

Emergence of cooperative bistability and robustness of gene regulatory networks.Semantic proximity Read ↗

Reliability of regulatory networks and its evolution.Semantic proximity Read ↗

Bistability in feedback circuits as a byproduct of evolution of evolvability.Semantic proximity Read ↗

Evolution of Boolean networks under selection for a robust response to external inputs yields an extensive neutral space.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.