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The CSN/COP9 signalosome regulates synaptonemal complex assembly during meiotic prophase I of Caenorhabditis elegans.

PLoS genetics - 1 Nov 2014

Brockway Heather, Balukoff Nathan, Dean Martha, Alleva Benjamin, Smolikove Sarit

Abstract excerpt

The synaptonemal complex (SC) is a conserved protein structure that holds homologous chromosome pairs together throughout much of meiotic prophase I. It is essential for the formation of crossovers, which are required for the proper segregation of chromosomes into gametes. The assembly of the SC is likely to be regulated by post-translational modifications. The CSN/COP9 signalosome has been shown to act in many...

Topics

Animals
COP9 Signalosome Complex
Caenorhabditis elegans
Chromosome Pairing
Chromosome Segregation
Crossing Over, Genetic
DNA Damage
DNA Repair
Meiosis
Meiotic Prophase I
Mitogen-Activated Protein Kinase Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multiprotein Complexes

Mutation

Peptide Hydrolases

Signal Transduction

Synaptonemal Complex

Source

Open in PubMed Open full text

Identifiers

PMID: 25375142
DOI: 10.1371/journal.pgen.1004757
PMCID: PMC4222726

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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The CSN/COP9 signalosome regulates synaptonemal complex assembly during meiotic prophase I of Caenorhabditis elegans.PMID 25375142Read ↗

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