Article
ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling.
Cell reports - 23 Oct 2014
Handschuh Karen, Feenstra Jennifer, Koss Matthew, Ferretti Elisabetta, Risolino Maurizio, Zewdu Rediet, Sahai Michelle A, Bénazet Jean-Denis, Peng Xiao P, Depew Michael J, Quintana Laura, Sharpe James, Wang Baolin, Alcorn Heather, Rivi Roberta, Butcher Stephen, Manak J Robert, Vaccari Thomas, Weinstein Harel, Anderson Kathryn V, Lacy Elizabeth, Selleri Licia
Abstract excerpt
Sorting and degradation of receptors and associated signaling molecules maintain homeostasis of conserved signaling pathways during cell specification and tissue development. Yet, whether machineries that sort signaling proteins act preferentially on different receptors and ligands in different contexts remains mysterious. Here, we show that Vacuolar protein sorting 25, Vps25, a component of ESCRT-II (Endosomal...
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