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Article

Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation.

Journal of cell science - 15 Dec 2007

Korolchuk Viktor I, Schütz Martin M, Gómez-Llorente Carolina, Rocha João, Lansu Nico R, Collins Stephanie M, Wairkar Yogesh P, Robinson Iain M, O'Kane Cahir J

Abstract excerpt

To identify novel proteins required for receptor-mediated endocytosis, we have developed an RNAi-based screening method in Drosophila S2 cells, based on uptake of a scavenger receptor ligand. Some known endocytic proteins are essential for endocytosis in this assay, including clathrin and alpha-adaptin; however, other proteins important for synaptic vesicle endocytosis are not required. In a small screen for...

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Identifiers

PMID: 18057029
DOI: 10.1242/jcs.012336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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