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Article

Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila.

Developmental cell - 1 Nov 2005

Thompson Barry J, Mathieu Juliette, Sung Hsin-Ho, Loeser Eva, Rørth Pernille, Cohen Stephen M

Abstract excerpt

We have found that the Drosophila gene vps25 possesses several properties of a tumor suppressor. First, vps25 mutant cells activate Notch and Dpp receptor signaling, inducing ectopic organizers in developing eyes and limbs and consequent overproliferation of both mutant and nearby wild-type cells. Second, as the mutant cells proliferate, they lose their epithelial organization and undergo apoptosis. Strikingly,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16256745
DOI: 10.1016/j.devcel.2005.09.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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