Article

Defects in exosome biogenesis are associated with sensorimotor defects in zebrafish <i>vps4a</i> mutants

2024-03-14

Abstract excerpt

Mutations in human VPS4A are associated with neurodevelopmental defects, including motor delays and defective muscle tone. VPS4A encodes a AAA-ATPase that is required for membrane scission, but how mutations in VPS4A lead to impaired control of motor function is not known. Here we identified a mutation in zebrafish vps4a , T248I, that affects sensorimotor transformation. In biochemical experiments we show that...

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Literature Corpus work: 75ca4224-12df-50f2-a7eb-a30a0eb01ab0
DOI: 10.1101/2024.03.13.584854

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