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Article

Defects in Exosome Biogenesis Are Associated with Sensorimotor Defects in Zebrafish vps4a Mutants.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Dec 2024

Shipman Anna, Gao Yan, Liu Desheng, Sun Shan, Zang Jingjing, Sun Peng, Syed Zoha, Bhagavathi Amol, Smith Eliot, Erickson Timothy, Hill Matthew, Neuhauss Stephan, Sui Sen-Fang, Nicolson Teresa

Abstract excerpt

Mutations in human VPS4A are associated with neurodevelopmental defects, including motor delays and defective muscle tone. VPS4A encodes a AAA-ATPase required for membrane scission, but how mutations in VPS4A lead to impaired control of motor function is not known. Here we identified a mutation in zebrafish vps4a, T248I, that affects sensorimotor transformation. Biochemical analyses indicate that the T248I...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39455257
DOI: 10.1523/JNEUROSCI.0680-24.2024
PMCID: PMC11638813

Genes

VPS4A
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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