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Article

A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations.

Genetic epidemiology - 1 Dec 2014

Evangelou Marina, Smyth Deborah J, Fortune Mary D, Burren Oliver S, Walker Neil M, Guo Hui, Onengut-Gumuscu Suna, Chen Wei-Min, Concannon Patrick, Rich Stephen S, Todd John A, Wallace Chris

Abstract excerpt

Pathway analysis can complement point-wise single nucleotide polymorphism (SNP) analysis in exploring genomewide association study (GWAS) data to identify specific disease-associated genes that can be candidate causal genes. We propose a straightforward methodology that can be used for conducting a gene-based pathway analysis using summary GWAS statistics in combination with widely available reference genotype...

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Share to Diabetes Mellitus, Type 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 25371288
DOI: 10.1002/gepi.21853
PMCID: PMC4258092

Genes

BAD
CTSB
FYN
ITGB1
ITGB7
NRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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