Article
A Powerful Procedure for Pathway-Based Meta-analysis Using Summary Statistics Identifies 43 Pathways Associated with Type II Diabetes in European Populations.
PLoS genetics - 1 Jun 2016
Zhang Han, Wheeler William, Hyland Paula L, Yang Yifan, Shi Jianxin, Chatterjee Nilanjan, Yu Kai
Abstract excerpt
Meta-analysis of multiple genome-wide association studies (GWAS) has become an effective approach for detecting single nucleotide polymorphism (SNP) associations with complex traits. However, it is difficult to integrate the readily accessible SNP-level summary statistics from a meta-analysis into more powerful multi-marker testing procedures, which generally require individual-level genetic data. We developed a...
Topics
- Diabetes Mellitus, Type 2
- Ethnicity
- Europe
- Gene Expression
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Humans
- Polymorphism, Single Nucleotide
- Signal Transduction