Article
CARD14 expression in dermal endothelial cells in psoriasis.
PloS one - 1 Jan 2014
Harden Jamie L, Lewis Steven M, Pierson Katherine C, Suárez-Fariñas Mayte, Lentini Tim, Ortenzio Francesca S, Zaba Lisa C, Goldbach-Mansky Raphaela, Bowcock Anne M, Lowes Michelle A
Abstract excerpt
Mutations in the caspase recruitment domain, family member 14 (CARD14) gene have recently been described in psoriasis patients, and explain the psoriasis susceptibility locus 2 (PSORS2). CARD14 is a scaffolding protein that regulates NF-κB activation, and psoriasis-associated CARD14 mutations lead to enhanced NF-κB signaling. CARD14 is expressed mainly in epidermal keratinocytes, but also in unidentified dermal...
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