Impact of the -1T>C single-nucleotide polymorphism of the CD40 gene on the development of endothelial dysfunction in a pro-diabetic microenvironment.

doi:10.1016/j.atherosclerosis.2023.117386

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Article

Impact of the -1T>C single-nucleotide polymorphism of the CD40 gene on the development of endothelial dysfunction in a pro-diabetic microenvironment.

Atherosclerosis - 1 Jul 2024

Joshi Pooja, Mohr Franziska, Rumig Cordula, Kliemank Elisabeth, Krenning Guido, Kopf Stefan, Hecker Markus, Wagner Andreas H

Abstract excerpt

BACKGROUND AND AIMS: Hyperglycemia reinforces pro-inflammatory conditions that enhance CD40 expression in endothelial cells (EC). Thymine to cytosine transition (-1T > C) in the promoter of the CD40 gene (rs1883832) further increases the abundance of CD40 protein on the EC surface. This study examines potential associations of the -1T > C SNP of the CD40 gene with type 1 (T1D) or type 2 (T2D) diabetes. Moreover,...

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PMID: 38030458
DOI: 10.1016/j.atherosclerosis.2023.117386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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