Article
RGS5 gene and therapeutic response to short acting bronchodilators in paediatric asthma patients.
Pediatric pulmonology - 1 Oct 2013
Labuda Malgorzata, Laberge Sophie, Brière Julie, Bérubé Denis, Krajinovic Maja
Abstract excerpt
Short-acting β2-adrenergic receptor agonists are commonly used bronchodilators for symptom relief in asthmatics. Recent evidence demonstrated that prolonged exposure of cultured airway smooth muscle cells to β2 agonists directly augments procontractile signaling pathways with the change in expression of regulator of G protein signaling 5 (RGS5). The aim of this study was to test whether genetic variants in RGS5...
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