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Retroviral integration and human gene therapy

1 Aug 2007

Abstract excerpt

Long-term correction of genetic diseases requires permanent integration of therapeutic genes into chromosomes of affected cells. Retroviral vectors are the most widely used delivery vehicles because of their efficiency and precision of integration. However, retroviral integration can take place at a variety of chromosomal sites, and examples have been reported of integration of therapeutic vectors activating...

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PMID: 17671645
DOI: 10.1172/jci32949

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