Article

LISA: A Comprehensive R Package for Lentiviral Integration Site Analysis in Gene Therapy Safety Assessment

2025-12-23

Abstract excerpt

<h4>Background</h4> Gene therapy using integrating viral vectors has shown remarkable clinical success, but the random integration of vectors into the host genome poses potential safety concerns, particularly insertional mutagenesis. Common Integration Sites (CIS) near oncogenes significantly increase the risk of clonal expansion and malignant transformation. Current tools for integration site (IS) analysis lack...

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Literature Corpus work: 1cb936c6-4267-551e-b946-de2bbaf112ee
DOI: 10.64898/2025.12.20.695672

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