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Retroviral Integration Site Selection

12 Jan 2010

Abstract excerpt

The stable insertion of a copy of their genome into the host cell genome is an essential step of the life cycle of retroviruses. The site of viral DNA integration, mediated by the viral-encoded integrase enzyme, has important consequences for both the virus and the host cell. The analysis of retroviral integration site distribution was facilitated by the availability of the human genome sequence, revealing the...

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PMID: 21994603
DOI: 10.3390/v2010111

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