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Article

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.

Blood - 1 Mar 2007

Kustikova Olga S, Geiger Hartmut, Li Zhixiong, Brugman Martijn H, Chambers Stuart M, Shaw Chad A, Pike-Overzet Karin, de Ridder Dick, Staal Frank J T, von Keudell Gottfried, Cornils Kerstin, Nattamai Kalpana Jekumar, Modlich Ute, Wagemaker Gerard, Goodell Margaret A, Fehse Boris, Baum Christopher

Abstract excerpt

Evidence from model organisms and clinical trials reveals that the random insertion of retrovirus-based vectors in the genome of long-term repopulating hematopoietic cells may increase self-renewal or initiate malignant transformation. Clonal dominance of nonmalignant cells is a particularly inte...

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Identifiers

PMID: 17119121
DOI: 10.1182/blood-2006-08-044156
PMCID: PMC1801061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17119121-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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