Article
Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.
Blood - 1 Mar 2007
Kustikova Olga S, Geiger Hartmut, Li Zhixiong, Brugman Martijn H, Chambers Stuart M, Shaw Chad A, Pike-Overzet Karin, de Ridder Dick, Staal Frank J T, von Keudell Gottfried, Cornils Kerstin, Nattamai Kalpana Jekumar, Modlich Ute, Wagemaker Gerard, Goodell Margaret A, Fehse Boris, Baum Christopher
Abstract excerpt
Evidence from model organisms and clinical trials reveals that the random insertion of retrovirus-based vectors in the genome of long-term repopulating hematopoietic cells may increase self-renewal or initiate malignant transformation. Clonal dominance of nonmalignant cells is a particularly interesting phenotype as it may be caused by the dysregulation of genes that affect self-renewal and competitive fitness....
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