Article
The NOD2 p.Leu1007fsX1008 mutation (rs2066847) is a stronger predictor of the clinical course of Crohn's disease than the FOXO3A intron variant rs12212067.
PloS one - 1 Jan 2014
Schnitzler Fabian, Friedrich Matthias, Wolf Christiane, Angelberger Marianne, Diegelmann Julia, Olszak Torsten, Beigel Florian, Tillack Cornelia, Stallhofer Johannes, Göke Burkhard, Glas Jürgen, Lohse Peter, Brand Stephan
Abstract excerpt
BACKGROUND: Very recently, a sub-analysis of genome-wide association scans revealed that the non-coding single nucleotide polymorphism (SNP) rs12212067 in the FOXO3A gene is associated with a milder course of Crohn's disease (CD) (Cell 2013;155:57-69). The aim of our study was to evaluate the clinical value of the SNP rs12212067 in predicting the severity of CD by correlating CD patient genotype status with the...
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