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Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia

1 Jan 2014

Abstract excerpt

Adoptive cell therapy utilizing ex vivo expanded polyclonal CD4 + CD25 + FOXP3 + regulatory T cells (Treg) is in use in clinical trials for the treatment of type 1 diabetes and prevention of graft versus host disease in bone marrow transplantation. Here, we seek to evaluate this approach in the treatment of inherited protein deficiencies, i.e. , hemophilia, which is often complicated by antibody formation against...

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PMID: 25364772
DOI: 10.1038/mtm.2014.30

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