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Chimeric Antigen Receptor Regulatory T Cell in Transplantation: The Future of Cell Therapy?

8 Apr 2022

Abstract excerpt

Adoptive immunotherapy with regulatory T cells (Tregs) has the potential for treatment of autoimmune disease and as immunosuppression after solid-organ transplantation. Tregs are CD4+ T lymphocytes that express the Forkhead box p3 transcription factor. These cells dampen immune responses through a number of different potential mechanisms. Until now, the only populations of Tregs administered by adoptive transfer...

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PMID: 35694556
DOI: 10.1016/j.ekir.2022.04.003

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