Article
Enhanced suppression of the xenogeneic T-cell response in vitro by xenoantigen stimulated and expanded regulatory T cells.
Transplantation - 15 Jan 2014
Jin Xi, Wang Ya, Hawthorne Wayne J, Hu Min, Yi Shounan, O'Connell Philip
Abstract excerpt
BACKGROUND: Strategies to prevent xenograft rejection while minimizing long-term immunosuppression need to be developed for successful xenotransplantaion. Polyclonally expanded human regulatory T cells (Treg) are known to suppress xenogeneic responses in vivo and in vitro. However, the risk of opportunistic infection and malignancy and the requirement for large numbers of Treg for effective suppression remain...
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