Article
Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase 2 genes on the metabolism of artemisinin-based combination therapies in malaria patients from Cambodia and Tanzania.
Antimicrobial agents and chemotherapy - 1 Feb 2013
Staehli Hodel Eva Maria, Csajka Chantal, Ariey Frédéric, Guidi Monia, Kabanywanyi Abdunoor Mulokozi, Duong Socheat, Decosterd Laurent Arthur, Olliaro Piero, Beck Hans-Peter, Genton Blaise
Abstract excerpt
The pharmacogenetics of antimalarial agents are poorly known, although the application of pharmacogenetics might be critical in optimizing treatment. This population pharmacokinetic-pharmacogenetic study aimed at assessing the effects of single nucleotide polymorphisms (SNPs) in cytochrome P450 isoenzyme genes (CYP, namely, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5) and the...
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