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Article

Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity.

The EMBO journal - 7 Mar 2007

Schwamborn Jens C, Müller Myriam, Becker Annemarie Hm, Püschel Andreas W

Abstract excerpt

The development of a polarised morphology with multiple dendrites and a single axon is an essential step in the differentiation of neurons. The establishment of neuronal polarity is directed by the sequential activity of the GTPases Rap1B and Cdc42. Rap1B is initially present in all neurites of unpolarised neurons, but becomes restricted to the tip of a single process during the establishment of neuronal polarity...

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Identifiers

PMID: 17318188
DOI: 10.1038/sj.emboj.7601580
PMCID: PMC1817628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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