Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Association between polymorphisms of TCF7L2 and type 2 diabetes with special reference to incretin action].

Nihon rinsho. Japanese journal of clinical medicine - 1 May 2011

Enya Mayumi, Horikawa Yukio, Takeda Jun

Abstract excerpt

TCF7L2 is a Wnt signaling-associated transcription factor and is ubiquitously expressed. Polymorphisms in the TCF7L2 gene exhibit the strongest association with type 2 diabetes among approximately twenty susceptibility gene variants identified to date. Although the mechanisms by which TCF7L2 affects susceptibility to type 2 diabetes remain to be elucidated, several studies have shown that decreased TCF7L2 protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 2
Share to GIP gene
Share to Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 21595284

Genes

GIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Association between polymorphisms of TCF7L2 and type 2 diabetes with special reference to incretin action].PMID 21595284Read ↗

The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus.Semantic proximity Read ↗

TCF7L2 genetic defect and type 2 diabetes.Semantic proximity Read ↗

The Role of TCF7L2 in Type 2 Diabetes.Semantic proximity Read ↗

Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function.Semantic proximity Read ↗

The broad pathogenetic role of TCF7L2 in human diseases beyond type 2 diabetes.Semantic proximity Read ↗

TCF7L2 and Glucose Metabolism: Time to Look Beyond the PancreasSemantic proximity Read ↗

Prime suspect: the TCF7L2 gene and type 2 diabetes risk.Semantic proximity Read ↗

What Can Diabetes-Associated Genetic Variation in TCF7L2 Teach Us About the Pathogenesis of Type 2 Diabetes?Semantic proximity Read ↗

Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.Semantic proximity Read ↗

The role of transcription factor 7‐like 2 in metabolic disordersSemantic proximity Read ↗

TCF7L2 gene variants predispose to the development of type 2 diabetes mellitus among individuals with metabolic syndromeSemantic proximity Read ↗

The new type 2 diabetes gene TCF7L2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.