Article
Association of ABCB1 genetic polymorphisms with susceptibility to colorectal cancer and therapeutic prognosis.
Pharmacogenomics - 1 Jun 2013
Wu Huizhe, Kang Hui, Liu Yong, Xiao Qinghuan, Zhang Yining, Sun Mingjun, Liu Duo, Wang Zhe, Zhao Haishan, Yao Weifan, Jia Tianhong, Wang Enhua, Zheng Zhihong, Wei Minjie
Abstract excerpt
AIM: To evaluate the association of ABCB1 gene polymorphisms with susceptibility to colorectal cancer (CRC) and clinical outcomes of CRC patients with chemotherapy. PATIENTS & METHODS: A case-control study was performed on the C3435T, C1236T and G2677T/A polymorphisms in the ABCB1 gene in 1028 CRC patients and 1230 controls. RESULTS: We observed that the ABCB1 C3435T and G2677T/A variants as well as the...
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