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Article

A gene-wide investigation on polymorphisms in the ABCG2/BRCP transporter and susceptibility to colorectal cancer.

Mutation research - 14 Oct 2008

Campa Daniele, Pardini Barbara, Naccarati Alessio, Vodickova Ludmila, Novotny Jan, Försti Asta, Hemminki Kari, Barale Roberto, Vodicka Pavel, Canzian Federico

Abstract excerpt

ATP-binding cassette (ABC) transporters actively export a wide variety of molecules from cells, contributing to reduce the local cellular burden of toxic compounds. ABCG2/BCRP is abundantly expressed in epithelial cells of the intestine and colon. The expression and activity of this transporter in the gut differ between individuals, due at least in part to genetic polymorphisms, which may thus affect the risk of...

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Source

Identifiers

PMID: 18775442
DOI: 10.1016/j.mrfmmm.2008.08.001

Genes

ABCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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