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Article

Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization.

Nucleic acids research - 10 Nov 2014

Kaikkonen Minna U, Niskanen Henri, Romanoski Casey E, Kansanen Emilia, Kivelä Annukka M, Laitalainen Jarkko, Heinz Sven, Benner Christopher, Glass Christopher K, Ylä-Herttuala Seppo

Abstract excerpt

Vascular endothelial growth factor A (VEGF-A) is a master regulator of angiogenesis, vascular development and function. In this study we investigated the transcriptional regulation of VEGF-A-responsive genes in primary human aortic endothelial cells (HAECs) and human umbilical vein endothelial cells (HUVECs) using genome-wide global run-on sequencing (GRO-Seq). We demonstrate that half of VEGF-A-regulated gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Enhancer Elements, Genetic

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Source

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Identifiers

PMID: 25352550
DOI: 10.1093/nar/gku1036
PMCID: PMC4227755

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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