Article
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.
Nature communications - 29 Oct 2014
van den Beucken Twan, Koch Elizabeth, Chu Kenneth, Rupaimoole Rajesha, Prickaerts Peggy, Adriaens Michiel, Voncken Jan Willem, Harris Adrian L, Buffa Francesca M, Haider Syed, Starmans Maud H W, Yao Cindy Q, Ivan Mircea, Ivan Cristina, Pecot Chad V, Boutros Paul C, Sood Anil K, Koritzinsky Marianne, Wouters Bradly G
Abstract excerpt
MicroRNAs are small regulatory RNAs that post transcriptionally control gene expression. Reduced expression of DICER, the enzyme involved in microRNA processing, is frequently observed in cancer and is associated with poor clinical outcome in various malignancies. Yet, the underlying mechanisms are not well understood. Here we identify tumour hypoxia as a regulator of DICER expression in large cohorts of breast...
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