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Pluripotent and Multipotent Stem Cells Display Distinct Hypoxic miRNA Expression Profiles

26 Oct 2016

Abstract excerpt

MicroRNAs are reported to have a crucial role in the regulation of self-renewal and differentiation of stem cells. Hypoxia has been identified as a key biophysical element of the stem cell culture milieu however, the link between hypoxia and miRNA expression in stem cells remains poorly understood. We therefore explored miRNA expression in hypoxic human embryonic and mesenchymal stem cells (hESCs and hMSCs). A...

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PMID: 27783707
DOI: 10.1371/journal.pone.0164976

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