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Article

Notch signaling in the malignant bone marrow microenvironment: implications for a niche‐based model of oncogenesis

28 Oct 2014

Abstract excerpt

Fueled by the growing interest in stem cell biology and the promise of regenerative medicine, study of the hematopoietic stem cell (HSC) microenvironment has provided critical insights into normal and malignant hematopoiesis. Notch receptor signaling in this microenvironment is a critical regulator of HSC fate and differentiation. Notch signaling also has the potential to modulate the growth of various malignant...

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PMID: 25351294
DOI: 10.1111/nyas.12562

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