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Article

The Hematopoietic Microenvironment in Myeloproliferative Neoplasms: The Interplay Between Nature (Stem Cells) and Nurture (the Niche).

Advances in experimental medicine and biology - 1 Jan 2020

Zhan Huichun, Kaushansky Kenneth

Abstract excerpt

Hematopoietic stem cells (HSCs) rely on instructive cues from the marrow microenvironment for their maintenance and function. Accumulating evidence indicates that the survival and proliferation of hematopoietic neoplasms are dependent not only on cell-intrinsic, genetic mutations, and other molecular alterations present within neoplastic stem cells, but also on the ability of the surrounding microenvironmental...

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PMID: 33119879
DOI: 10.1007/978-3-030-49270-0_7

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