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Article

Mapping and targeting of the leukemic microenvironment

24 Dec 2019

Abstract excerpt

Numerous studies support a role of the microenvironment in maintenance of the leukemic clone, as well as in treatment resistance. It is clear that disruption of the normal bone marrow microenvironment is sufficient to promote leukemic transformation and survival in both a cell autonomous and non-cell autonomous manner. In this review, we provide a snapshot of the various cell types shown to contribute to the...

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Share to Acute Myeloid Leukemia Research
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Identifiers

PMID: 31873722
DOI: 10.1084/jem.20190589

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