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Article

The arginine decarboxylase pathways of host and pathogen interact to impact inflammatory pathways in the lung.

PloS one - 1 Jan 2014

Paulson Nick B, Gilbertsen Adam J, Dalluge Joseph J, Welchlin Cole W, Hughes John, Han Wei, Blackwell Timothy S, Laguna Theresa A, Williams Bryan J

Abstract excerpt

The arginine decarboxylase pathway, which converts arginine to agmatine, is present in both humans and most bacterial pathogens. In humans agmatine is a neurotransmitter with affinities towards α2-adrenoreceptors, serotonin receptors, and may inhibit nitric oxide synthase. In bacteria agmatine serves as a precursor to polyamine synthesis and was recently shown to enhance biofilm development in some strains of the...

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Identifiers

PMID: 25350753
DOI: 10.1371/journal.pone.0111441
PMCID: PMC4211729

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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