Article

Spermidine and spermine are the natural substrates of the <i>Acinetobacter baumannii</i> AmvA multidrug efflux pump

2020-10-03

Abstract excerpt

Multidrug efflux pumps are important drivers of antibiotic resistance in Acinetobacter baumannii and other pathogens, however their ‘natural’ roles beyond transport of clinical antimicrobials are poorly described. Polyamines are an ancient class of molecules with broad roles in all three kingdoms of life, and are the likely natural substrate of at least one efflux pump family. We have defined the transcriptome of...

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Literature Corpus work: 9ccd98e1-642b-5687-845e-01027e346ce2
DOI: 10.1101/2020.10.02.324624

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