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Article

MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma

25 Jan 2011

Abstract excerpt

BACKGROUND: Neuroblastoma is a paediatric cancer which originates from precursor cells of the sympathetic nervous system and accounts for 15% of childhood cancer mortalities. With regards to the role of miRNAs in neuroblastoma, miR-34a, mapping to a chromosome 1p36 region that is commonly deleted, has been found to act as a tumor suppressor through targeting of numerous genes associated with cell proliferation...

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PMID: 21266077
DOI: 10.1186/1471-2407-11-33

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