Sirt1 sustains sonic hedgehog signaling to promote medulloblastoma progression through regulating Gli3 processing

Abstract excerpt

<title>Abstract</title> <p> Medulloblastoma (MB), the most common malignant pediatric brain tumor with poor prognosis, high recurrence, and severe treatment-related toxicities. One-third of MB are driven by aberrant activation of the Sonic hedgehog (SHH) signaling pathway. In current study, through analysis of clinical patient cohorts and animal model database, and utilizing genetically engineered primary and xe...

Topics

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• Autophagy in Disease and Therapy
• Cell Proliferation
• Cerebellar Neoplasms
• Glioma Diagnosis and Treatment
• Hedgehog Signaling Pathway Studies
• Histone Deacetylase Inhibitors Research
• PARP inhibition in cancer therapy
• Sirtuins and Resveratrol in Medicine

Identifiers and source

Literature Corpus work

be10e061-6ae8-5dc1-8e09-21acefe2d37f

DOI

10.21203/rs.3.rs-7344210/v1