Article
Effect of oligonucleotide probes substituted by deoxyinosines on the specificity of SNP detection on the DNA microarray.
Electrophoresis - 1 Jan 2015
Qian Xiaoting, Pu Dan, Liu Bicheng, Xiao Pengfeng
Abstract excerpt
One of the main factors that can affect the quality of microarray results is the microarray hybridization specificity. The key factor that affects hybridization specificity is the design of the probes. In this paper, we described a novel oligonucleotide probe containing deoxyinosines aimed at improving DNA hybridization specificity. We compared different probes to determine the distance between deoxyinosine base...
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