Article
Structure-function relationships of three kinds of immobilized DNA probes in the discrimination abilities of single nucleotide variation.
Journal of nanoscience and nanotechnology - 1 Mar 2012
Bai Yunfei, Han Qin, Lin Dai, Luo Junfeng, Tu Jin, Ge Qinyu, Lu Zuhong
Abstract excerpt
We have compared here the nucleic acid hybridization abilities of three kinds of immobilized probes with different structures. Under the conventional structural design, we found that the share-stem hairpin structure probe (SHP) was more easily hybridized with the target than the linear probe and conventional hairpin shaped probe (HP). The HP probe had the lowest hybridization ability. However, it was shown a...
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