Article
Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis.
JAMA - 5 Nov 2014
Smith J Gustav, Luk Kevin, Schulz Christina-Alexandra, Engert James C, Do Ron, Hindy George, Rukh Gull, Dufresne Line, Almgren Peter, Owens David S, Harris Tamara B, Peloso Gina M, Kerr Kathleen F, Wong Quenna, Smith Albert V, Budoff Matthew J, Rotter Jerome I, Cupples L Adrienne, Rich Stephen, Kathiresan Sekar, Orho-Melander Marju, Gudnason Vilmundur, O'Donnell Christopher J, Post Wendy S, Thanassoulis George
Abstract excerpt
IMPORTANCE: Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression. OBJECTIVE: To evaluate whether genetic data are consistent with an association between LDL-C, high-density lipoprotein...
Topics
Join the communities discussing this publication.