Article
Benefits of Better Cardiovascular Health for Calcific Aortic Valve Stenosis Stratified by Polygenic Risk Score.
Genomics, proteomics & bioinformatics - 28 Oct 2025
Zhu 朱岳鑫 Yuexin, Chen 陈秋丽 Qiuli, Qiao 乔博康 Bokang, Jia 贾立昕 Lixin, Wen 温海初 Haichu, Pan 潘威 Wei, Wang 王一帆 Yifan, Mi 米双利 Shuangli, Wang 汪敏先 Minxian, Du 杜杰 Jie
Abstract excerpt
With global aging, the prevalence of calcific aortic valve stenosis (CAVS) has significantly increased, and even mild CAVS elevates mortality risk, highlighting an urgent need for preventive strategies. In this study, we analyzed 153,312 participants from the UK Biobank. We found that a higher Life's Essential 8 (LE8) score was independently associated with a decreased CAVS risk [hazard ratio (HR)/standard...
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