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Article

FoxA4 favours notochord formation by inhibiting contiguous mesodermal fates and restricts anterior neural development in Xenopus embryos.

PloS one - 1 Jan 2014

Murgan Sabrina, Castro Colabianchi Aitana Manuela, Monti Renato José, Boyadjián López Laura Elena, Aguirre Cecilia E, Stivala Ernesto González, Carrasco Andrés E, López Silvia L

Abstract excerpt

In vertebrates, the embryonic dorsal midline is a crucial signalling centre that patterns the surrounding tissues during development. Members of the FoxA subfamily of transcription factors are expressed in the structures that compose this centre. Foxa2 is essential for dorsal midline development in mammals, since knock-out mouse embryos lack a definitive node, notochord and floor plate. The related gene foxA4 is...

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PMID: 25343614
DOI: 10.1371/journal.pone.0110559
PMCID: PMC4208771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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