Article
Maintenance of the specification of the anterior definitive endoderm and forebrain depends on the axial mesendoderm: a study using HNF3beta/Foxa2 conditional mutants.
Developmental biology - 1 Mar 2002
Hallonet Marc, Kaestner Klaus H, Martin-Parras Luis, Sasaki Hiroshi, Betz Ulrich A K, Ang Siew-Lan
Abstract excerpt
In mouse embryo, the early induction of the head region depends on signals from the anterior visceral endoderm (AVE) and the anterior primitive streak. Subsequently, node derivatives, including anterior definitive endoderm and axial mesendoderm, are thought to play a role in the maintenance and elaboration of anterior neural character. Foxa2 encodes a winged-helix transcription factor expressed in signaling...
Topics
- Animals
- Body Patterning
- DNA-Binding Proteins
- Embryonic and Fetal Development
- Endoderm
- Gene Expression Regulation, Developmental
- Hepatocyte Nuclear Factor 3-beta
- Immunohistochemistry
- In Situ Hybridization
- Mesoderm
- Mice
- Mutation